Neurosciences, Neurodegenerative diseases, Alzheimer's didease

Funding: Alzheimer's Association Fellowship Grant; 2017-2020

April 14, 2016	Postdoctoral Fellow & Research Associate Award for Excellence in Research 2016. Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA.
May 21, 2015	The Post-doctoral Neurosciences Award. Neurological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
2007-2011	Research Assistantship. Chosun University, Gwangju, Republic of Korea.
2007-2009	Foreign Students Scholarship. Chosun University, Gwangju, Republic of Korea.
2006	Effective Performance Award. Nestle Bangladesh Ltd., Dhaka, Bangladesh.
2005	Best Achievement Award. Nestle Bangladesh Ltd., Dhaka, Bangladesh.
2002	Talentful Stipend. Rajshahi University, Rajshahi, Bangladesh.
2000	Gold Medal Award. Shaheed Ziaur Rahman Hall, Rajshahi University, Bangladesh.

Cleveland Clinic Lerner Research Institute, Cleveland Ohio 44195 USA/ Case Western Researve University, Cleveland, Ohio
Research Associate / Adjunct Instructor

My research focuses on several pathological aspect of Alzheimer’s diseases (AD), including biological functions of β-amyloid cleaving enzyme 1 (BACE1) and dystrophic neurites (DNs). Our group was the first to report that BACE1 activity is naturally inhibited by a protein called reticulon 3 (RTN3). In line with this finding, we have elucidated that BACE1 protein level and its activity are enhanced in RTN3 deficient condition (Shi & Ge et. al., 2014). Our lab also determined that RTN3 plays another roles in AD by formation of DNs surrounding amyoid palque. Recently I have discovered that such RTN3 mediated DNs in AD patient’s brain are formed by clustering of tubular endoplasmic reticulum (ER) (Sharoar et. al., 2016). This is the first report in AD research field showing that tubular ER constitutes a pathological feature of AD that contributes to cognitive impairment. 

1. Qi Shi, Yinging Ge, Md.Golam Sharoar, Wanxia He, Rong Xiang, Z Zhang, Xiangyou Hu, Riqiang Yan. Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition. Journal of Neurosciences, 34(42):13954-62.doi: 10.1523/JNEUROSCI.1588-14.2014.

2. Md. Golam Sharoar, Qi Shi, Yingying Ge, Wanxia He, Xiangyou Hu, George Perry, Xiongwei Zhu and Riqiang Yan. Dysfunctional tubular endoplasmic reticulum induces formation of dystrophic neurites in Alzheimer’s disease. Molecular Psychiatry, 21, 1263-1271 (September 2016) doi:10.1038/mp.2015.181

3. Md. Golam Sharoar and Riqiang Yan. Effects of altered RTN3 expression on BACE1 activity and Alzheimer’s neuritic plaques. Reviews in the Neurosciences, 2016 (accepted).

 

PEER-REVIEWED ARTICLES

Md. Golam Sharoar and Riqiang Yan. Effects of altered RTN3 expression on BACE1 activity and Alzheimer’s neuritic plaques. Reviews in the Neurosciences, 28(2):145-154; 2017. Md. Golam Sharoar, Qi Shi, Yingying Ge, Wanxia He, Xiangyou Hu, George Perry, Xiongwei Zhu and Riqiang Yan. Dysfunctional tubular endoplasmic reticulum induces formation of dystrophic neurites in Alzheimer’s disease. Molecular Psychiatry, 21, 1263-1271; 2016. Qi Shi, Yinging Ge, Md.Golam Sharoar, Wanxia He, Rong Xiang, Z Zhang, Xiangyou Hu, Riqiang Yan. Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition. Journal of Neurosciences, 34(42):13954-62; 2014.   Full list of publications:  https://www.ncbi.nlm.nih.gov/pubmed/?term=sharoar