Heartiest congratulation to Dr. Tofazzal Islam and his associates for publishing the following article in the Frontiers in Microbiology. The full article article may be viewed by clicking following link: Inhibitory effects of macrotetrolides from Streptomyces spp. on zoosporogenesis and motility of peronosporomycete zoospores are likely linked with enhanced ATPase activity in mitochondria. The lead author Professor Tofazzal Islam has summarized the article as lollows;
In this article, we reported that marine macrotetrolide antibiotics from Streptomyces spp. inhibit motility and viability of zoospores of the notorious Peronosporomycete phytopathogens such as Phytophthora capsici, Plasmopara viticola, and Aphanomyces cochlioides. Our findings suggest that motility inhibition of zoospores by the macrotetrolide antibiotics is linked with enhanced activity of ATPase enzyme in mitochondria of zoospores. Enhanced activity of ATPase limits the steady supply of ATP for high energy demanding specialized cells, zoospores. We also found that macrotetrolides also suppress the release of zoospores from the sporangia. As release of zoospores and their motility are critical for infection by the Peronosporomycete phytopathogens, impairment of motility of zoospores by natural products (macrotetrilides) would lead to the development of novel strategy for management of the zoosporic phytopathogens.