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Chromosome Biorientation during Cell Division facilitated by Chromosomal Passenger Complex

Chromosome Biorientation during Cell Division facilitated by Chromosomal Passenger Complex

In an article entitled, ‘Tension sensing by Aurora B kinase is independent of survivin-based centromere localization,’ published in  the 2ndMay, 2013 issue of Nature, (vol  497:121), Christopher, S. Campbell and Arshad Desai at the University of California, School of Medicine, San Diego, Ca describe  that the segregation of the replicated genome requires chromosome biorientation on the spindle.  Recent studies at  1.4 Angstrom  resolution of the crystal structure of the regulatory core of the CPC  (chromosomal passenger complex)  reveal that it is more complex than it was hitherto thought. CPC has been observed to consist of three sub-structures:  Survivin, Borealin, and INCENP. They are the three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. Biorientation on the spindle is ensured by Aurora B kinase (Ipl1). This specific enzyme  –  a member of CPC  functions in the attachment of the mitotic spindle to the centromere.  It is the  localization of the CPC to the inner centromere that initiates the process. This model  describes  how tension ensures chromosome biorientation, i.e., tension free kinetochore–spindle attachments  close to the inner centromere. They are destabilized by Aurora B phosphorylation, whereas kinetochores under tension are pulled away from the influence of Aurora . This process  supports proper chromosome segregation during both mitosis and meiosis.

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