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Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation

Dhaka the 9th Oct., ’13. In an article, “Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation,” published on the 3rd October issue of Nature (vol.502:110-113), Lilian Kabeche & Duane A. Compton affiliated to Norris Cotton Cancer Center, Lebanon, New Hampshire have shown that k–MT attachments in prometaphase cells are considerably less stable than  those at metaphase cells and that the switch to more stable k–MT attachments in metaphase requires the proteasome-dependent destruction of cyclin A in prometaphase. They have further shown that persistent cyclin A expression prevents k–MT stabilization even in cells with aligned chromosomes.

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