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Impact of the mechanical pressure during cell division

Impact of the mechanical pressure during cell division

In an article entitled, “Tissue dynamics with permeation”, published in June 15, 2012, issue of The European Physical Journal E 35: 46 1-13, the lead author J. Ranft with three other associates from three research groups studied the relative impact of the mechanical pressure influenced by dividing cells. This approach complements conventional studies on genetic and biochemical signaling mechanisms to clarify investigatory observations on biological tissues maturity. The research team shaped a two-component mathematical model accounting for both the cells and the fluid caught in between. On one hand, cells are modeled as behaving like a dividing fluid subject to expansion. On the other hand, the interstitial fluid is similar to a model fluid that cannot be compressed. Interestingly, the authors found that only the cells’ pressure influences the level of cell division. Moreover, the homeostatic pressure is balanced through programmed cell death when many cells are produced by cell division. This leads to a steady state of the biological tissue. The authors also pinpointed the range of fluid pressure required to drive cell flow within the body. Such models will surely assist to better understanding on the importance of the disruption of homeostatic pressure in biological tissues caused by cancer cells. [summarized by a graduate student Samsad Razzaque]

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