Probable correlation between physical fitness of children and their mother’s gastrointestinal bypass surgery

Probable correlation between physical fitness of children and their mother’s gastrointestinal bypass surgery

In an article entitled, ‘Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery,’ published in May 28, 2013, issue of PNAS ( doi:10.1073/pnas.1216959110 ), the lead author Frédéric Guénard with five other associates from four different institutes have reported differences in gene methylation that might underlie the improved markers of cardiovascular health observed in children born to mothers after gastrointestinal bypass surgery compared with siblings born before the surgery. Previous studies have found lower occurrence of obesity, less adiposity, less hypertension, and greater insulin sensitivity in children born to women who underwent gastrointestinal bypass surgery for weight loss compared with siblings born before the surgery. To test the effects of the surgery on genetic markers of heart health in the offspring, Marie-Claude Vohl and colleagues recruited 20 unrelated 35-51-year-old mothers residing in and around Québec City who had undergone a type of gastrointestinal bypass surgery called biliopancreatic distraction with duodenal switch to treat severe obesity. The authors performed gene expression analysis on a cohort of 25 offspring born before the mothers had the surgery and 25 siblings born after the surgery; the offspring varied in age from 2 to 25 years. The authors found that 5,698 genes, notably those involved in inflammation, vascular disease, and the control of glucose metabolism, were differentially methylated between the two sibling groups. Further, the authors observed correlations between gene methylation levels and the functions of genes implicated in cardiovascular disease and diabetes, suggesting potential mechanisms underlying metabolic improvements previously reported in offspring born after the surgery. According to the authors, the findings suggest links between a maternal surgical intervention, changes in the uterine environment, and offspring gene expression. Only time will tell if these youngsters born after mom’s surgery really get lasting benefits, whatever the reason. Meanwhile, specialists urge women planning a pregnancy to talk with their doctors about their weight ahead of time. Besides having potential long-term consequences, extra weight can lead to a variety of immediate complications such as an increased risk of premature birth and cesarean sections. [Summarized by Samsad Razzaque– a graduate student in Plant Biotech Lab. DU]

Recent News


February 2017
Su Mo Tu We Th Fr Sa
29 30 31 1 2 3 4
5 6 7 8 9 10 11
12 13 14 15 16 17 18
19 20 21 22 23 24 25
26 27 28 29 1 2 3