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Transcriptome in vivo analysis of spatially defined single cells in live tissue

Transcriptome in vivo analysis of spatially defined single cells in live tissue

January 18, ’14. In an article, “Transcriptome in vivo  analysis  of spatially defined single cells  in live tissue,” published on the 16th January issue of Nature, (vol.505:264), Ditte Lovatt and 17 of his associates have described a unique technique to retrieve RNA from intact tissue revealing the expression of the genes resident in that cell.

The earlier methods of single-cell RNA retrieval tend to disrupt the surrounding tissue before the RNA is  derived. James Eberwine  of the University of Pennsylvania in Philadelphia and 17 of his colleagues created a template. By adding the tag to human and mouse brain tissue and shining a laser on individual cells, the researchers could activate the tag, retrieve the RNA and sequence  it.

The approach could reveal how a cell’s natural microenvironment  affect its activity.

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