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UvrD facilitates DNA repair by pulling RNA polymerase backwards

UvrD facilitates DNA repair by pulling RNA polymerase backwards

Dhaka, the 19th Jan., ’14. In an article  titled, “UvrD facilitates DNA repair by pulling RNA polymerase backwards,”  published on the 16thJanuary issue of Nature (505:372-377), the lead author Evgeny Nudler and five of his associates at Howard Hughes Medical Institute, New York and two  at the Russian Academy of Science, Moscow showed that Escherichia coli UvrD binds RNA polymerase during transcription elongation. Using its helicase/translocase activity, it forces RNA polymerase to slide backward along DNA. They have now confirmed that UvrD is a transcription elongation factor that binds RNA polymerase and promotes its backward movement when it slows down at a lesion point. They have further reported that NusA, another elongation factor, assists in promoting backtracking and helps UvrD to target other nucleotide excision repair factors to the exposed lesion.

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