Medicinal chemistry Design, synthesis, purification, and characterisation of small-molecule drugs. These efforts are essential in the development of new therapeutic agents, ensuring that each compound is carefully synthesised and rigorously tested to meet the highest standards of efficacy and safety.

Analytical Chemistry Monitoring of chemical synthesis is carried out using cutting-edge techniques like LC/MS and NMR, ensuring precise and accurate analysis at every stage of the process.

Cell culture Primary and secondary human and mouse cell lines for assessing their response against drugs

1. Commonwealth PhD Scholarship in the United Kingdom (2019-2023)
2. Japanese Government MEXT Scholarship at Tottori University, 2015
3. Vice-Chancellor Distinction Award (For excellent result in MS)
4. Vice-Chancellor Distinction Award (For excellent result in B.Sc.)
5. Graduate Academic Excellence Stipend, Faculty of Life Sciences, Shahjalal University of Science and Technology, Bangladesh
6. Shahjalal University Merit Scholarship for excellent results.

Development of next generation of payloads Design, synthesis, purification, and characterisation of a new generation of Pyrrolobenzodiazepines to be used as payloads for the Antibody-drug Conjugates (ADCs).

Patents We have filed a patent (UK Patent Application No. 2405758.0 by King's College London) and now working on the PCT submission.

(1)        Procopiou, G.; Jackson, P. J.; Andriollo, P.; Hasan, M. M.; Veillard, N.; Rahman, K. M.; Thurston, D. E. Synthesis of novel pyrrolobenzodiazepine (PBD) C1-substituted monomers and dimers with DNA-binding activity and cytotoxicity. Bioorganic & Medicinal Chemistry Letters 2025, 130095.

(2)        Surani, Y. M.; Wand, M.; Picconi, P.; Di Palma, M.; Chiozzi, R. Z.; Hasan, M. M.; Maynard-Smith, M.; Steiner, R.; Rahman, K. M.; Hind, C. Convergent evolution of antibiotic resistance mechanisms between synthetic pyrrolobenzodiazepines (PBDs) and the naturally occurring albicidin in multidrug resistant Klebsiella pneumoniae. 2024.

(3)        Siam, M. H. B.; Hasan, M. M.; Rahman, M. M.; Rouf, R. R.; Hossain, M. S. Why COVID-19 Symptomatic Patients Did Not Seek Healthcare Service at the Early Phase of the Pandemic in Bangladesh: Evidence From a Cross-Sectional Study. Cureus 2024, 16 (7), e65145.

(4)        Hasan, M.; Saha, C.; Mannan, A. Genetic determinants of SARS-CoV-2 and the clinical outcome of COVID-19 in Southern Bangladesh. Immun Inflamm Dis 2024, 12 (Feb 2024), e1171.

(5)        Chen, Y.; Li, Y.; Hind, C.; Hasan, M. M.; Nahar, K.; Clifford, M.; Sutton, J. M.; Rahman, K. M. New generation modified azole antifungals against multidrug-resistant Candida auris. 2024.

(6)        Mahbubul H. Siddiqee, B. B., Mahbub Hasan, Mohammad Shojon, Mehedi Hassan, Rashawan Raziur Rouf, Umme Raihan Siddiqi, Fazlay Rabbi; Siddiqi, U. R. Risk perception of sun exposure and knowledge of vitamin D among the healthcare providers in a high-risk country: a cross-sectional study. BMC Medical Education 2023, 23 (2023), 43.

(7)        Hasan, M. M.; Uddin, K. M. K.; Lokman, S. M.; Chakma, K.; Pulu, A. C.-U.; Mannan, A.; Raheem, E.; Chowdhury, S. A.; Hossain, M. S. Knowledge and attitudes of thalassaemia among high-risk indigenous university students in Bangladesh: A pilot study. PLOS ONE 2023,  (0287630).

(8)        Tanni, A. A.; Sultana, N.; Ahmed, W.; Hasan, M. M.; Hossain, M. S.; Noyon, S. H.; Hossain, M. M.; Mannan, A. Investigating Antimicrobial Resistance and ESBL Producing Gene in Klebsiella Isolates among Neonates and Adolescents in Southern Bangladesh. Canadian Journal of Infectious Diseases and Medical Microbiology 2022, 2022 (1), 7071009.

(9)        Salauddin, A.; Chakma, K.; Hasan, M. M.; Akter, F.; Chowdhury, N. A.; Chowdhury, S. R.; Mannan, A. Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case–control study among the Bangladeshi population. Molecular Biology Reports 2022,  (https://doi.org/10.1007/s11033-022-08081).

(10)      Mannan, A.; Akter, F.; A. Chy, N. U. H.; Alam, N.; Rana, M. M.; Asgar Chowdhury, N.; Hasan, M. M. The relationship between medical comorbidities and health-related quality of life among adults with type 2 diabetes: The experience of different hospitals in southern Bangladesh. PLOS ONE 2022, 17 (5), e0267713.

(11)      Joseph, A. M.; Nahar, K.; Daw, S.; Hasan, M. M.; Lo, R.; Le, T.; Rahman, K. M.; Badrinarayanan, A. Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage. RSC Medicinal Chemistry 2022.

(12)      Tanni, A. A.; Hasan, M. M.; Sultana, N.; Ahmed, W.; Mannan, A. Prevalence and molecular characterization of antibiotic resistance and associated genes in Klebsiella pneumoniae isolates: A clinical observational study in different hospitals in Chattogram, Bangladesh. PLOS One 2021, 16 (9), e0257419.

(13)      Siam, M. H. B.; Hasan, M. M.; Tashrif, S. M.; Khan, M. H. R.; Raheem, E.; Hossain, M. S. Insights into the first seven-months of COVID-19 pandemic in Bangladesh: lessons learned from a high-risk country. Heliyon 2021, 7 (6).

(14)      Siam, M. H.; Hasan, M. M.; Rahman, M. M.; Rouf, R. R.; Hossain, M. S. Why COVID-19 symptomatic patients did not seek healthcare service in Bangladesh: evidence from a cross-sectional study. 2021.

(15)      Mannan, A.; Hasan, M. M.; Akter, F.; Rana, M. M.; Chowdhury, N. A.; Rawal, L. B.; Biswas, T. Factors associated with low adherence to medication among patients with type 2 diabetes at different healthcare facilities in southern Bangladesh. Global health action 2021, 14 (1), 1872895.

(16)      Laws, M.; Surani, Y. M.; Hasan, M.; Chen, Y.; Jin, P.; Al-Adhami, T.; Chowdhury, M.; Imran, A.; Psaltis, I.; Jamshidi, S. Current trends and future approaches in small-molecule therapeutics for COVID-19. Current Medicinal Chemistry 2021, 28 (19), 3803-3824.

(17)      Hossain, M. S.; Hasan, M. M.; Petrou, M.; Telfer, P.; Al Mosabbir, A. The Parental Perspective of Thalassaemia in Bangladesh: Lack of knowledge, Regret, and Barriers. Orphanet Journal of Rare Diseases 2021, 2021 (16), 315.

(18)      Hasan, M. M.; Das, R.; Rasheduzzaman, M.; Hussain, M. H.; Muzahid, N. H.; Salauddin, A.; Rumi, M. H.; Rashid, S. M.; Siddiki, A. Z.; Mannan, A. Global and local mutations in Bangladeshi SARS-CoV-2 genomes. Virus research 2021, 297, 198390.

(19)      Hasan, M.; Laws, M.; Jin, P.; Rahman, K. Factors influencing the choice of monoclonal antibodies for antibody–drug conjugates. Drug Discovery Today 2021, https://doi.org/10.1016/j.drudis.2021.1009.

(20)      Hakim, A.; Hasan, M.; Hasan, M.; Lokman, S.; Azim, K.; Raihan, T.; Azad, P. C. A. Major Insights in Dynamics of Host Response to SARS-CoV-2: Impacts and Challenges. Frontiers in Microbiology 2021, 12, 2384.

(21)      Gomez, C. R.; Espinoza, I.; Faruque, F. S.; Hasan, M. M.; Rahman, K. M.; Walker, L. A.; Muhammad, I. Therapeutic intervention of COVID-19 by natural products: a population-specific survey directed approach. Molecules 2021, 26 (4), 1191.

(22)      Azad, A.; Ahmed, J.; Hakim, A.; Hasan, M.; Alum, M.; Hasan, M. Genome-wide Characterization Deciphers Distinct Properties of Aquaporins in Six Phytophthora species. Current Bioinformatics 2021, 16 (1).

(23)      Lokman, S. M.; Rasheduzzaman, M.; Salauddin, A.; Barua, R.; Tanzina, A. Y.; Rumi, M. H.; Hossain, M. I.; Siddiki, A. Z.; Mannan, A.; Hasan, M. M. Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: a computational biology approach. Infection, Genetics and Evolution 2020, 84, 104389.

(24)      Hossain, M. S.; Hasan, M. M.; Raheem, E.; Islam, M. S.; Al Mosabbir, A.; Petrou, M.; Telfer, P.; Siddiqee, M. H. Lack of knowledge and misperceptions about thalassaemia among college students in Bangladesh: a cross-sectional baseline study. Orphanet Journal of Rare Diseases 2020, 15, 1-10.

(25)      Akter, F.; Mannan, A.; Mehedi, H. H.; Rob, M. A.; Ahmed, S.; Salauddin, A.; Hossain, M. S.; Hasan, M. M. Clinical characteristics and short term outcomes after recovery from COVID-19 in patients with and without diabetes in Bangladesh. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2020, 14 (6), 2031-2038.

(26)      Deeba, I. M.; Hasan, M. M.; Al Mosabbir, A.; Siam, M. H. B.; Islam, M. S.; Raheem, E.; Hossain, M. S. Manifestations of atypical symptoms of Chikungunya during the Dhaka outbreak (2017) in Bangladesh. The American journal of tropical medicine and hygiene 2019, 100 (6), 1545.

(27)      Hossain, M. S.; Hasan, M. M.; Islam, M. S.; Islam, S.; Mozaffor, M.; Khan, M. A. S.; Ahmed, N.; Akhtar, W.; Chowdhury, S.; Arafat, S. Y. Chikungunya outbreak (2017) in Bangladesh: Clinical profile, economic impact and quality of life during the acute phase of the disease. PLoS neglected tropical diseases 2018, 12 (6), e0006561.

(28)      Azad, A. K.; Ahmed, J.; Alum, M. A.; Hasan, M. M.; Ishikawa, T.; Sawa, Y. Prediction of arsenic and antimony transporter major intrinsic proteins from the genomes of crop plants. International Journal of Biological Macromolecules 2018, 107, 2630-2642.

(29)      Saha, C. K.; Hasan, M. M.; Hossain, M. S.; Jahan, M. A.; Azad, A. K. In silico identification and characterization of common epitope-based peptide vaccine for Nipah and Hendra viruses. Asian Pacifc Journal of Tropical Medicine 2017, 10 (6), 529-538.

(30)      Marzan, L. W.; Sultana, T.; Hasan, M. M.; Mina, S. A.; Islam, M. R.; Rakibuzzaman, A.; Khan, M. I. H. Characterization of furnace oil bioremediation potential of hydrocarbonoclastic bacteria isolated from petroleum contaminated sites of the Sundarbans, Bangladesh. Journal of Genetic Engineering and Biotechnology 2017, 15 (1), 103-113.

(31)      Hasan, M. M.; Raheem, E.; Sultana, T. A.; Hossain, M. S. Pattern of hematological malignancies in adolescents and young adults in Bangladesh. Cancer Epidemiology 2017, 51, 109-112.

(32)      Hasan, M. M.; Marzan, L. W.; Hosna, A.; Hakim, A.; Azad, A. K. Optimization of some fermentation conditions for the production of extracellular amylases by using Chryseobacterium and Bacillus isolates from organic kitchen wastes. Journal of Genetic Engineering and Biotechnology 2017, 15 (1), 59-68.

(33)      Azad, A. K.; Ahmed, J.; Alum, M. A.; Hasan, M. M.; Ishikawa, T.; Sawa, Y.; Katsuhara, M. Genome-Wide Characterization of Major Intrinsic Proteins in Four Grass Plants and Their Non-Aqua Transport Selectivity Profiles with Comparative Perspective. PLoS ONE 2016, 11 (6), e0157735.

(34)      Azad, A.; Yousuf, A.; Ferdoush, A.; Hasan, M.; Karim, M.; Jahan, A. Production of microbial lipids from rice straw hydrolysates by Lipomyces starkeyi for biodiesel synthesis. J Microb Biochem Technol S 2014, 8 (2).

(35)      Sohag, M. M. H.; Hasan, M. M.; Ahmed, J.; Daud, S. N. A.; Alam, M. K.; Amin, M. R.; Hoq, M. M.; Azad, A. K. Production and Partial Characterization of Cellulase from Pseudomonas Isolates Obtained from Cow Dung and Municipal Solid Wastes. Bangladesh Journal of Microbiology 2013, 30 (1&2), 11-16.

(36)      Azad, A. K.; Nahar, A.; Hasan, M. M.; Islam, K.; Azim, M. F.; Hossain, M. S.; Rahman, M. R.; Ojha, R. K.; Mahmud, G. M. S.; Kayes, R. Fermentation of municipal solid wastes by bacterial isolates for production of raw protein degrading proteases. Asian Journal of Microbiology, Biotechnology & Environmental Sciences 2013, 15 (2), 365-374.

(37)      Azad, A. K.; Hasan, M. M.; Hossain, M. S.; Rahman, M. R.; Chowdhury, P. A. In silico analysis of outer membrane protein 31 of brucella spp. to identify and characterize the potential T cell epitope. International Journal of Pharmacy and Pharmaceutical Sciences 2013, 2 (3), 28-45.

(38)      Azad, A. K.; Jahan, M. A.; Hasan, M. M.; Ishikawa, T.; Sawa, Y.; Shibata, H. Molecular cloning and sequence and 3D models analysis of the Sec61α subunit of protein translocation complex from Penicillium ochrochloron. BMB Reports 2011, 44 (11), 719-724.